8-{1-[(4′-Fluoro-[1,1′-biphen­yl]-4-yl)meth­yl]piperidin-4-yl}-3,4-di­hydro­quinolin-2(1H)-one chloro­form 0.25-solvate

In the asymmetric unit of the title compound, C27H27FN2O·0.25CHCl3, there are two independent mol-ecules (A and B) together with a partially disordered chloro-form mol-ecule situated about an inversion center. The conformation of the two mol-ecules is very similar. The bridging piperidine rings each have a chair conformation while the piperidin-2-one rings of the quinoline moiety have screw-boat conformations. The benzene rings of the biphenyl moiety are inclined to one another by 26.37 (4) and 23.75 (15)° in mol-ecules A and B, respectively. The mean plane of the central piperidine ring [r.m.s. deviation = 0.241 (2) Å in both mol-ecules A and B] is inclined to the benzene ring of the quinoline moiety by 80.06 (4) in A and 83.75 (15)° in B, while it is inclined to the adjacent benzene ring of the biphenyl group by 73.623 (15) in A and 75.65 (14)° in B. In the crystal, individual mol-ecules are linked by pairs of N-H⋯O hydrogen bonds, forming A-A and B-B inversion dimers with R 2 (2)(8) ring motifs. The dimers are stabilized by C-H⋯O hydrogen bonds and linked via C-H⋯F and C-H⋯N hydrogen bonds into a three-dimensional network. Several C-H⋯π inter-actions are also present.